. . . . Information and Availability of Naturally Occuring Mind Altering Substances . . . .

Salvinorin A

The most active constituent of Salvia divinorum is believed to be a chemical called salvinorin-A, C23H28O8.

Chemical name:
acetoxy-2-(furan-3-yl)-6a,10b-dimethyl-4,10- dioxo-dodecahydro-1H-benzo[f]isochromene-7-carboxylate

Its presence in the body is not detectable by current drug tests. The chemical appears not to be habit-forming nor tolerance forming, on the contrary after repeated exposure, some users report a "reverse-tolerance" or sensitization, where less of the chemical is subsiquently required to produce the same subjective effects.

The diterpene salvinorin A from Salvia divinorum is active in doses of 200-500 µg (0.2-0.5mg), making it the most potent naturally-occurring entheogenic chemical yet discovered. It is a high-affinity and selective kappa-opioid receptor agonist, and by itself produces effects which are subjectively very similar to those experienced when the whole herb is ingested.

Salvinorin A is effectively deactivated by the gastrointestinal system, so alternative routes of absorption must be used to maintain its activity. Traditionally Mazatec shamans consume the herb either by chewing the fresh leaves or by drinking the juices of freshly crushed leaves. The effects of the herb when consumed this way depend on absorption of salvinorin A through the oral mucosa before the herb is swallowed. Emphasis is placed on holding the leaves (and also the saliva secreted during chewing) in the mouth as long as possible, to facilitate absorption through the oral mucosa.

Salvia seems to have somewhat of a disassociative effect, and like other dissociatives, hallucinations are perceived most often (at lower dosages) only in a dark room or closed eye environment.

Most users find that the effects of salvinorin are not very conducive to socializing or getting high at parties; in fact, while under the influence most people tend to find any external stimuli distracting. Small doses are preceived as mind clearing and coordination impairing; many find a small dose useful for meditation. Consciousness is retained until the very highest doses, but body control, awareness of externalities, and individual identity disappear at modest ones.

Large doses have more dramatic effects. Taking a moderate to large dose induces a trancelike state, in which the user may experience fully formed visions of other places, people, and events. "Bad trips" are rare but do happen. If inhaled, the effects do not last long relative to most recreational drugs, with the main experience lasting only 5 minutes and generally ending completely within 10. Chewing and ingestion cause longer-lasting, but generally somewhat milder effects. About 10% of people seem unaffected by Salvia, though through gradual micro-dosing most could likely attain effects.

                Salvinorin Extract Photos


Salvinorin is not normally sold to the public in pure form (for obvious reasons), though "X" extracts of Salvia divinorum are available, containing as much as 40X the salvinorin A as unenhanced leaf.

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